MTMR3 - myotubularin related protein 3
Entrez Gene Name: myotubularin related protein 3
Entrez GeneID: Human(8897)
, Mouse(74302), Rat(305482)
, Mouse(74302), Rat(305482) Synonyms: 1700092A20Rik, AI255150, AW557713, FLJ32333, FYVE ZINC FINGER PTP, FYVE-DSP1, KIAA0371, MGC78036, mKIAA0371, MTMR3, ZFYVE10
Gene Summary
- Human (8897): This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
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Biological Process
dephosphorylation, phospholipid dephosphorylation, protein amino acid dephosphorylation
Literature References
- 16319195Hartman SE, Bertone P, Nath AK, Royce TE, Gerstein M, Weissman S, Snyder M. Global changes in STAT target selection and transcription regulation upon interferon treatments.Genes Dev 2005 Dec 15;19(24):2953-68
- 12080474Manzano RG, Montuenga LM, Dayton M, Dent P, Kinoshita I, Vicent S, Gardner GJ, Nguyen P, Choi YH, Trepel J, Auersperg N, Birrer MJ. CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential.Oncogene 2002 Jun 27;21(28):4435-47
- 17339486Deem TL, Abdala-Valencia H, Cook-Mills JM. VCAM-1 Activation of Endothelial Cell Protein Tyrosine Phosphatase 1B.J Immunol 2007 Mar 15;178(6):3865-73 View 11 categorized literature findings and their references in IPA
Molecular Functions
hydrolase activity, inositol or phosphatidylinositol phosphatase activity, metal ion binding, phosphatase activity, phosphoprotein phosphatase activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, zinc ion binding
Protein Domains
FYVE domain, phosphatase, protein serine/threonine phosphatase, protein-tyrosine-phoshatase, zinc ion binding
