ANG - angiogenin, ribonuclease, RNase A family, 5
Entrez Gene Name: angiogenin, ribonuclease, RNase A family, 5
Entrez GeneID: Human(283)
, Mouse(11727), Rat(305843)
, Mouse(11727), Rat(305843) Synonyms: AI385586, ALS9, ANG, Ang1, Ang2, ANGIOGENIN, ANGIOGENIN 2, BRB, MGC140149, MGC22466, MGC71966, RNASE4, RNASE5, Rnase5a
Gene Summary
- Human (283): The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
actin filament polymerization, activation of phospholipase A2, activation of phospholipase C activity, activation of protein kinase B activity, angiogenesis, cell communication, cell differentiation, cell migration, central nervous system development, diacylglycerol biosynthetic process, homeostatic process, multicellular organismal development, negative regulation of smooth muscle cell proliferation, negative regulation of translation, oocyte maturation, ovarian follicle development, placenta development, positive regulation of endothelial cell proliferation, positive regulation of phosphorylation, positive regulation of protein secretion, response to hormone stimulus, response to hypoxia, rRNA transcription
Cellular Components
angiogenin-PRI complex, basal lamina, cell soma, extracellular region, extracellular space, growth cone, nucleolus, nucleus
Literature References
- 15735021Tsuji T, Sun Y, Kishimoto K, Olson KA, Liu S, Hirukawa S, Hu GF. Angiogenin Is Translocated to the Nucleus of HeLa Cells and Is Involved in Ribosomal RNA Transcription and Cell Proliferation.Cancer Res 2005 Feb 15;65(4):1352-60
- 15558023Kishimoto K, Liu S, Tsuji T, Olson KA, Hu GF. Endogenous angiogenin in endothelial cells is a general requirement for cell proliferation and angiogenesis.Oncogene 2005 Jan 13;24(3):445-56
- 12118120Kao RY, Jenkins JL, Olson KA, K Ey ME, Fett JW, Shapiro R. A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.Proc Natl Acad Sci U S A 2002 07 23;99(15):10066-71 View 272 categorized literature findings and their references in IPA
Molecular Functions
actin binding, copper ion binding, DNA binding, endonuclease activity, heparin binding, hydrolase activity, nuclease activity, nucleic acid binding, pancreatic ribonuclease activity, peptide binding, receptor binding, ribonuclease activity, RNA binding, rRNA binding
Protein Domains
actin binding, copper ion binding, endonuclease, enzyme, heparin binding, Non-5' phosphomonoester producing endoribonuclease, receptor binding, ribonuclease, rRNA binding
