ELA1 - elastase 1, pancreatic
Entrez Gene Name: elastase 1, pancreatic
Entrez GeneID: Human(1990)
, Mouse(109901), Rat(24331)
, Mouse(109901), Rat(24331) Synonyms: 1810009A17Rik, 1810062B19Rik, ELA1, ELAI1, Elastase1, PC-TsF, RATELAI1
Gene Summary
- Human (1990): Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.
- Rat (24331): catalyzes the hydrolysis of elastin and other proteins [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
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Literature References
- 15161642Fontaine V, Touat Z, Mtairag el M, Vranckx R, Louedec L, Houard X, Andreassian B, Sebbag U, Palombi T, Jacob MP, Meilhac O, Michel JB. Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus.Am J Pathol 2004 Jun 01;164(6):2077-87
- 12393522El Ouriaghli F, Fujiwara H, Melenhorst JJ, Sconocchia G, Hensel N, Barrett AJ. Neutrophil elastase enzymatically antagonizes the in vitro action of G- CSF: implications for the regulation of granulopoiesis.Blood 2003 Mar 1;101(5):1752-8
- 10995768Viswanath RL, Rose SD, Swift GH, MacDonald RJ. A binary mechanism for the selective action of a pancreatic beta -cell transcriptional silencer.J Biol Chem 2000 Dec 22;275(51):40273-81 View 189 categorized literature findings and their references in IPA
Molecular Functions
calcium ion binding, hydrolase activity, pancreatic elastase I activity, peptidase activity, serine-type endopeptidase activity
