PDGFB - platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Entrez Gene Name: platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Entrez GeneID: Human(5155)
, Mouse(18591), Rat(24628)
, Mouse(18591), Rat(24628) Synonyms: C-SIS, FLJ12858, Pdgf beta, PDGF2, PDGFB, Pdgfrb, SIS, SSV
Gene Summary
- Human (5155): The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.
- Rat (24628): may play a role in carotid artery smooth muscle cell proliferation and neointimal formation in response to balloon catheter injury [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
actin cytoskeleton organization and biogenesis, cell growth, cell projection biogenesis, cell proliferation, DNA replication, negative regulation of cell migration, negative regulation of phosphatidylinositol biosynthetic process, negative regulation of platelet activation, platelet-derived growth factor receptor signaling pathway, positive regulation of blood vessel endothelial cell migration, positive regulation of chemotaxis, positive regulation of DNA replication, positive regulation of endothelial cell proliferation, positive regulation of fibroblast proliferation, positive regulation of MAP kinase activity, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, regulation of cell proliferation, regulation of peptidyl-tyrosine phosphorylation, response to estradiol stimulus, response to estrogen stimulus, response to hypoxia, response to organic substance, response to wounding, substrate-bound cell migration, transforming growth factor beta receptor signaling pathway, wound healing
Cellular Components
cell surface, cytoplasm, extracellular region, extracellular space, membrane, platelet dense granule lumen
Literature References
- 11230698Hobson JP, Rosenfeldt HM, Barak LS, Olivera A, Poulton S, Caron MG, Milstien S, Spiegel S. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.Science 2001 Mar 2;291(5509):1800-3
- 11157165Tang DG, Tokumoto YM, Apperly JA, Lloyd AC, Raff MC. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells.Science 2001 Feb 2;291(5505):868-71
- 10966456Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology.Annu Rev Biochem 2000;69:145-82 View 4505 categorized literature findings and their references in IPA
Molecular Functions
cell surface binding, growth factor activity, platelet-derived growth factor binding, platelet-derived growth factor receptor binding, protein binding, protein heterodimerization activity, protein homodimerization activity
