CHRM1 - cholinergic receptor, muscarinic 1
Entrez Gene Name: cholinergic receptor, muscarinic 1
Entrez GeneID: Human(1128)
, Mouse(12669), Rat(25229)
, Mouse(12669), Rat(25229) Synonyms: Achr, CHRM1, HM1, M1, M1 MACHR, M1 MUSCARINIC RECEPTOR, M1R, MGC30125, MUSCARINIC RECEPTOR SUBTYPE 1
Gene Summary
- Human (1128): The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq]
- Rat (25229): plays a role in acetylcholine receptor signaling and neuromuscular synaptic transmission [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
acetylcholine receptor signaling, muscarinic pathway, activation of protein kinase C activity, G-protein coupled receptor protein signaling pathway, muscarinic acetylcholine receptor, phospholipase C activating pathway, nervous system development, neuromuscular synaptic transmission, positive regulation of cell proliferation, protein modification process, regulation of locomotion, signal transduction
Cellular Components
cell junction, integral to membrane, integral to plasma membrane, membrane, membrane fraction, plasma membrane, postsynaptic membrane, synapse
Literature References
- 12743035Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.EMBO J 2003 May 15;22(10):2411-2421
- 17428986Alfa Cissé M, Sunyach C, Slack BE, Fisher A, Vincent B, Checler F. M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity.J Neurosci 2007 Apr 11;27(15):4083-92
- 17222678Oki T, Kageyama A, Takagi Y, Uchida S, Yamada S. Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder.J Urol 2007 Feb 01;177(2):766-70 View 1004 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, muscarinic acetylcholine receptor activity, phosphoinositide phospholipase C activity, receptor activity, rhodopsin-like receptor activity, signal transducer activity
