FES - feline sarcoma oncogene
Entrez Gene Name: feline sarcoma oncogene
Entrez GeneID: Human(2242)
, Mouse(14159), Rat(361597)
, Mouse(14159), Rat(361597) Synonyms: AI586313, BB137047, C-FES, FES, FPS, RGD1564385, RGD1564385 predicted, V-FPS
Gene Summary
- Human (2242): This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell proliferation, multicellular organismal development, protein amino acid phosphorylation
Literature References
- 12093729Mitsui N, Inatome R, Takahashi S, Goshima Y, Yamamura H, Yanagi S. Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.EMBO J 2002 07 1;21(13):3274-85
- 17595334Voisset E, Lopez S, Dubreuil P, De Sepulveda P. The tyrosine kinase FES is an essential effector of KITD816V proliferation signal.Blood 2007 Oct 01;110(7):2593-9
- 16455651Delfino FJ, Stevenson H, Smithgall TE. A Growth-suppressive Function for the c-Fes Protein-Tyrosine Kinase in Colorectal Cancer.J Biol Chem 2006 Mar 31;281(13):8829-35 View 354 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity
Protein Domains
FCH domain, kinase, kinase domain, Protein kinase, protein-tyrosine kinase, SH2 domain
Subcellular Locations
cytoplasm, growth cone, microtubules, neurites, neuronal varicosities, perinuclear region
