KLK3 - kallikrein-related peptidase 3
Entrez Gene Name: kallikrein-related peptidase 3
Entrez GeneID: Human(354)
, Mouse(16617), Rat(408242)
, Mouse(16617), Rat(408242) Synonyms: APS, Gk11, Gk27, Gk6, hK3, Klk1b24, Klk1b27, Klk1c6, Klk24, KLK27, KLK2A1, KLK3, Klk6, mGk-24, mGK-27, PKAL, PLASMA PREKALLIKREIN, prostate specific antigen, PSA, rGK-6
Gene Summary
- Human (354): Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Literature References
- 17452459Dong X, Sweet J, Challis JR, Brown T, Lye SJ. Transcriptional Activity of Androgen Receptor Is Modulated by Two RNA Splicing Factors, PSF and p54nrb.Mol Cell Biol 2007 Jul 01;27(13):4863-75
- 16951173Litvinov IV, Vander Griend DJ, Xu Y, Antony L, Dalrymple SL, Isaacs JT. Low-calcium serum-free defined medium selects for growth of normal prostatic epithelial stem cells.Cancer Res 2006 Sep 01;66(17):8598-607
- 16452400Yang CC, Ku CY, Wei S, Shiau CW, Chen CS, Pinzone JJ, Ringel MD, Chen CS. Peroxisome Proliferator-Activated Receptor {gamma}-Independent Repression of Prostate-Specific Antigen Expression by Thiazolidinediones in Prostate Cancer Cells.Mol Pharmacol 2006 May 01;69(5):1564-70 View 698 categorized literature findings and their references in IPA
Molecular Functions
catalytic activity, hydrolase activity, peptidase activity, serine-type endopeptidase activity, tissue kallikrein activity, trypsin activity
