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TUBA8 - tubulin, alpha 8
Entrez Gene Name: tubulin, alpha 8
Entrez GeneID: Human(51807), Mouse(53857), Rat(500377)
Synonyms: LOC682022, TUBA8, TUBAL2

Gene Summary

No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • Kinesin
  • Dynein
  • GTP
View all 15 in IPA
Regulated by:
  • paclitaxel
  • HDAC6
  • carbamylcholine
View all 116 in IPA
Binds:
  • MYC
  • TCP1
  • CLIP1
View all 88 in IPA
Role in cell:
  • morphology
  • binding
  • apoptosis
View all 7 in IPA
Disease:
  • tumor
  • non-small-cell lung carcinoma
  • prostatic carcinoma
View all 85 in IPA

Biological Process

microtubule cytoskeleton organization and biogenesis, microtubule-based movement, microtubule-based process, protein polymerization

Cellular Components

microtubule, protein complex

Literature References

  • 12486001Chen D, Wang M, Zhou S, Zhou Q. HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.EMBO J 2002 Dec 16;21(24):6801-6810
  • 12606581Zhang Y, Li N, Caron C, Matthias G, Hess D, Khochbin S, Matthias P. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo.EMBO J 2003 Mar 3;22(5):1168-1179
  • 15737990Yang F, Jiang Q, Zhao J, Ren Y, Sutton MD, Feng J. Parkin Stabilizes Microtubules through Strong Binding Mediated by Three Independent Domains.J Biol Chem 2005 Apr 29;280(17):17154-62
    • View 1132 categorized literature findings and their references in IPA

Molecular Functions

GTP binding, GTPase activity, nucleotide binding, structural constituent of cytoskeleton, structural molecule activity

Pathways

Protein Domains

GTPase domain, structural constituent of cytoskeleton

Subcellular Locations

No Data Available

IPA Extras