TPM3 - tropomyosin 3
Entrez Gene Name: tropomyosin 3
Entrez GeneID: Human(7170)
, Mouse(59069), Rat(117557)
, Mouse(59069), Rat(117557) Synonyms: CYTOSKELETAL TROPOMYOSIN, FLJ41118, gamma-TM, hscp30, hTM30nm, hTMnm, LOC286890, MGC102590, MGC14582, MGC3261, MGC72094, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, Tm5NM, Tm5nm1-2, Tpm-5, TPM3, TPMsk3, TRK, Trop-5, TROPOMYOSIN 3, Tropomyosin gamma, Tropomyosin2, TROPOMYOSIN5
Gene Summary
- Human (7170): This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Rat (117557): rod-like protein associated with actin filament in nonmuscle cells; may mediate the stability of actin filaments; may play a role in the regulation of cell transformation, cytokinesis, motility, and morphogenesis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Cellular Components
cleavage furrow, cortical cytoskeleton, cytoplasm, cytoskeleton, filamentous actin, growth cone, muscle thin filament tropomyosin, neuron projection, podosome
Literature References
- 11483508Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N. Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.EMBO J 2001 08 1;20(15):4041-54
- 16434395Kong KY, Kedes L. Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres.J Biol Chem 2006 Apr 07;281(14):9589-99
- 15317845Bakin AV, Safina A, Rinehart C, Daroqui C, Darbary H, Helfman DM. A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells.Mol Biol Cell 2004 Oct 01;15(10):4682-94 View 530 categorized literature findings and their references in IPA
Subcellular Locations
actin stress fibers, cell body, cytoplasm, cytoskeletal fraction, cytosol, golgi/trans-golgi network-rich vesicle fraction, neurites, phagosomes
