WIPF1 - WAS/WASL interacting protein family, member 1
Entrez Gene Name: WAS/WASL interacting protein family, member 1
Entrez GeneID: Human(7456)
, Mouse(215280), Rat(117538)
, Mouse(215280), Rat(117538) Synonyms: AI115543, D2Ertd120e, MGC111041, PRPL-2, WASPIP, WIP, WIPF1
Gene Summary
- Human (7456): This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.
- Rat (117538): binds the rat Wiskott-Aldrich syndrome protein homolog; may mediate mobilization of actin from stress fibers to form new actin filaments [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
actin cytoskeleton organization and biogenesis, actin filament-based movement, actin polymerization and/or depolymerization, cell morphogenesis, protein complex assembly
Cellular Components
actin cytoskeleton, actin filament, cytoplasm, cytoplasmic vesicle, cytoskeleton
Literature References
- 14757742Kettner A, Kumar L, Antón IM, Sasahara Y, De La Fuente M, Pivniouk VI, Falet H, Hartwig JH, Geha RS. WIP Regulates Signaling via the High Affinity Receptor for Immunoglobulin E in Mast Cells.J Exp Med 2004 Feb 02;199(3):357-68
- 12437929Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA. Structure of the N-WASP EVH1 Domain-WIP Complex. Insight into the Molecular Basis of Wiskott-Aldrich Syndrome.Cell 2002 Nov 15;111(4):565-76
- 16990791Lee S, Lee K, Hwang S, Kim SH, Song WK, Park ZY, Chang S. SPIN90/WISH interacts with PSD-95 and regulates dendritic spinogenesis via an N-WASP-independent mechanism.EMBO J 2006 10 18;25(20):4983-95 View 252 categorized literature findings and their references in IPA
Subcellular Locations
actin filaments, cell cortex, cytoplasm, lysosome fractions, perinuclear region, podosomes
