SMARCA2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Entrez Gene Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Entrez GeneID: Human(6595)
, Mouse(67155), Rat(361745)
, Mouse(67155), Rat(361745) Synonyms: 2610209L14RIK, BAF190, brahma, BRM, FLJ36757, HBRM, hSNF2a, MGC74511, SMARCA2, SNF2, SNF2alpha, SNF2L2, SNF2LA, Sth1p, SWI2
Gene Summary
- Human (6595): The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
- Rat (361745): mouse homolog plays a role in regulation of cell proliferation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
establishment and/or maintenance of chromatin architecture, negative regulation of cell proliferation, nucleosome assembly, regulation of transcription from RNA polymerase II promoter, transcription
Literature References
- 12757710Iakova P, Awad SS, Timchenko NA. Aging Reduces Proliferative Capacities of Liver by Switching Pathways of C/EBPalpha Growth Arrest.Cell 2003 May 16;113(4):495-506
- 12065415Wang S, Zhang B, Faller DV. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth.EMBO J 2002 Jun 17;21(12):3019-28
- 11238380Sif S, Saurin AJ, Imbalzano AN, Kingston RE. Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.Genes Dev 2001 Mar 1;15(5):603-18 View 595 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, DNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding, transcription coactivator activity
Protein Domains
ATP binding, bromodomain, carboxy terminal domain, DNA binding, helicase, Helicase domain, LXCXE binding site, N-terminal domain, nucleic acid binding, proline/glutamine rich region, protein binding, retinoblastoma protein binding domain, transcription co-activator, transcription regulator
Subcellular Locations
cellular membrane, chromatin fraction, cytoplasm, nuclear fraction, nuclear matrix fraction, nucleoplasm, nucleus
