KIF11 - kinesin family member 11
Entrez Gene Name: kinesin family member 11
Entrez GeneID: Human(3832)
, Mouse(16551), Rat(171304)
, Mouse(16551), Rat(171304) Synonyms: EG5, HKSP, KIF11, Kif8, Kifl1, KNSL1, TRIP5
Gene Summary
- Human (3832): This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.
- Rat (171304): participates in motile activities within the cell [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell cycle, cell division, microtubule-based movement, mitosis, mitotic centrosome separation, mitotic spindle organization and biogenesis, spindle pole body organization and biogenesis
Cellular Components
kinesin complex, microtubule, microtubule associated complex, spindle microtubule, spindle pole
Literature References
- 17974955Castillo A, Morse HC, Godfrey VL, Naeem R, Justice MJ. Overexpression of eg5 causes genomic instability and tumor formation in mice.Cancer Res 2007 Nov 01;67(21):10138-47
- 9742151Ferhat L, Cook C, Chauviere M, Harper M, Kress M, Lyons GE, Baas PW. Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development.J Neurosci 1998 Oct 1;18(19):7822-35
- 9235942Blangy A, Arnaud L, Nigg EA. Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150.J Biol Chem 1997 Aug 1;272(31):19418-24 View 135 categorized literature findings and their references in IPA
Subcellular Locations
axon branches, cell body, centriole, centrosome, cytoplasm, lamellipodia, microtubule aster fraction, microtubule bundles, nerve ending, nucleus, pericentrosomal region, postmitotic bridges, spindle pole
