HK2 - hexokinase 2
Entrez Gene Name: hexokinase 2
Entrez GeneID: Human(3099)
, Mouse(15277), Rat(25059)
, Mouse(15277), Rat(25059) Synonyms: AI642394, DKFZp686M1669, HEXOKINASE 2, Hexokinase ii, HK2, HKII, HXK2, TYPE II HEXOKINASE
Gene Summary
- Human (3099): Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
- Rat (25059): enzyme involved in the phosphorylation of glucose to produce glucose-6-phosphate; may be involved in the increased rate of glycolysis seen in cancer cells [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
carbohydrate phosphorylation, glucose catabolic process, glucose metabolic process, glycolysis, lactation
Literature References
- 18039843Sun L, Shukair S, Naik TJ, Moazed F, Ardehali H. Glucose Phosphorylation and Mitochondrial Binding Are Required for the Protective Effects of Hexokinases I and II.Mol Cell Biol 2008 Feb 01;28(3):1007-17
- 15627654Gosmain Y, Dif N, Berbe V, Loizon E, Rieusset J, Vidal H, Lefai E. Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues.J Lipid Res 2005 Apr 01;46(4):697-705
- 12483532Debatin KM, Poncet D, Kroemer G. Chemotherapy: targeting the mitochondrial cell death pathway.Oncogene 2002 Dec 12;21(57):8786-8803 View 391 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, catalytic activity, hexokinase activity, kinase activity, nucleotide binding, transferase activity
