CYB5R3 - cytochrome b5 reductase 3
Entrez Gene Name: cytochrome b5 reductase 3
Entrez GeneID: Human(1727)
, Mouse(109754), Rat(25035)
, Mouse(109754), Rat(25035) Synonyms: 0610016L08Rik, 2500002N19Rik, B5R, C85115, CYB5R3, DIA1, NADH Cytochrome B5 Reductase, NADHCB5, WU:AL591952.1-001, WU:AL591952.1-002, WU:AL591952.1-003, WU:Cyb5r3
Gene Summary
- Human (1727): This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. These two forms are resulted from alternative splicing of the gene. Mutations in this gene cause methemoglobinemias.
- Rat (25035): catalyzes the conversion of NADH, H+, and 2 ferricytochrome b(5) to NAD+ and 2 ferrocytochrome b(5) [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
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Biological Process
blood circulation, cholesterol biosynthetic process, lipid biosynthetic process, oxidation reduction, steroid biosynthetic process, sterol biosynthetic process
Cellular Components
cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, hemoglobin complex, membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion, soluble fraction
Literature References
- 9639531Bulbarelli A, Valentini A, DeSilvestris M, Cappellini MD, Borgese N. An erythroid-specific transcript generates the soluble form of NADH-cytochrome b5 reductase in humans.Blood 1998 Jul 1;92(1):310-9
- 10678165Tominaga T, Sahai E, Chardin P, McCormick F, Courtneidge SA, Alberts AS. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.Mol Cell 2000 Jan 1;5(1):13-25
- 15738266Colombo S, Longhi R, Alcaro S, Ortuso F, Sprocati T, Flora A, Borgese N. N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning.J Cell Biol 2005 Feb 28;168(5):735-45 View 62 categorized literature findings and their references in IPA
Molecular Functions
ADP binding, AMP binding, cytochrome-b5 reductase activity, electron carrier activity, FAD binding, NAD binding, oxidoreductase activity
Protein Domains
AMP binding, Cytochrome-b5 reductase, enzyme, FAD binding, FAD binding domain, NAD binding domain
Subcellular Locations
cytoplasm, cytosol, detergent resistant lipid raft fraction, endoplasmic reticulum, endoplasmic reticulum membrane, Golgi membranes, lipid droplets, midbody, mitochondria, nuclear envelope, peroxisomes, pH resistant lipid raft fraction
