GABBR1 - gamma-aminobutyric acid (GABA) B receptor, 1
Entrez Gene Name: gamma-aminobutyric acid (GABA) B receptor, 1
Entrez GeneID: Human(2550)
, Mouse(54393), Rat(81657)
, Mouse(54393), Rat(81657) Synonyms: bM573K1.1, dJ271M21.1.1, dJ271M21.1.2, FLJ92613, GABA B1, GABA B1 A, GABAB(1e), GABAB-R1, GABBR1, GABBR1-3, GB1, GBR1, GPRC3A, hGB1a
Gene Summary
- Human (2550): Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.
- Rat (81657): metabotropic G-protein-coupled receptor for gamma-aminobutyric acid (GABA) [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
antigen processing and presentation, G-protein coupled receptor protein signaling pathway, gamma-aminobutyric acid signaling pathway, immune response, negative regulation of adenylate cyclase activity, osteoblast differentiation, protein modification process, signal transduction
Cellular Components
cell junction, cytoplasm, extracellular region, integral to membrane, integral to plasma membrane, membrane, MHC class I protein complex, plasma membrane, postsynaptic membrane, synapse
Literature References
- 11498050Schuler V, Lüscher C, Blanchet C, Klix N, Sansig G, Klebs K, Schmutz M, Heid J, Gentry C, Urban L, Fox A, Spooren W, Jaton AL, Vigouret J, Pozza M, Kelly PH, Mosbacher J, Froestl W, Käslin E, Korn R, Bischoff S, Kaupmann K, van der Putten H, Bettler B. Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).Neuron 2001 Jul 19;31(1):47-58
- 9872316White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH. Heterodimerization is required for the formation of a functional GABA(B) receptor.Nature 1998 Dec 17;396(6712):679-82
- 9872317Kaupmann K, Malitschek B, Schuler V, Heid J, Froestl W, Beck P, Mosbacher J, Bischoff S, Kulik A, Shigemoto R, Karschin A, Bettler B. GABA(B)-receptor subtypes assemble into functional heteromeric complexes.Nature 1998 Dec 17;396(6712):683-7 View 436 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, GABA-B receptor activity, metabotropic glutamate, GABA-B-like receptor activity, olfactory receptor activity, protein binding, receptor activity, signal transducer activity
Protein Domains
carboxy terminal domain, coiled-coil domain, extracellular ligand binding domain, G-protein coupled receptor, GABA-B receptor, protein binding, short consensus repeat domain
Subcellular Locations
cell body, cell surface, cellular membrane, cis Golgi cisternae, cytoplasm, dendrites, dendritic spines, endoplasmic reticulum, endoplasmic reticulum-rich vesicle fraction, Golgi-enriched fraction, granules, intracellular space, membrane fraction, membrane processes, neurites, nuclear fraction, perinuclear region, perinuclear vesicles, plasma membrane, postsynaptic density (PSD) fractions, synaptosomes
