KITLG (includes EG:4254) - KIT ligand
Entrez Gene Name: KIT ligand
Entrez GeneID: Human(4254)
, Mouse(17311), Rat(60427)
, Mouse(17311), Rat(60427) Synonyms: C-KIT LIGAND, Clo, CON, contrasted, DKFZp686F2250, Gb, KIT LIGAND, KITL, KITLG (includes EG:4254), Kl, KL-1, Kl2, Mast cell factor, MGF, SCF, SCF RECEPTOR LIGAND, SF, SHEP7, SL, SLF, STEEL, STEEL FACTOR, Stem cell factor
Gene Summary
- Human (4254): This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene.
- Rat (60427): stimulates proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow cultures and interacts with the basic fibroblast growth factor (bFGF) to promote the primordial to primary follicle transition in rat ovaries [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell adhesion, cell proliferation, germ cell development, hemopoiesis, negative regulation of apoptosis, neural crest cell migration, ovarian follicle development, positive regulation of cell proliferation, positive regulation of DNA replication, positive regulation of MAP kinase activity, positive regulation of melanocyte differentiation, positive regulation of myeloid leukocyte differentiation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of Ras protein signal transduction, signal transduction
Cellular Components
cytoplasm, cytoskeleton, extracellular region, extracellular space, integral to membrane, membrane, plasma membrane
Literature References
- 11136826Hsieh FH, Lam BK, Penrose JF, Austen KF, Boyce JA. T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4.J Exp Med 2001 Jan 1;193(1):123-33
- 9565637Tajima Y, Huang EJ, Vosseller K, Ono M, Moore MA, Besmer P. Role of dimerization of the membrane-associated growth factor kit ligand in juxtacrine signaling: the Sl17H mutation affects dimerization and stability-phenotypes in hematopoiesis.J Exp Med 1998 May 4;187(9):1451-61
- 17556359Li B, Berman J, Tang JT, Lin TJ. The Early Growth Response Factor-1 Is Involved in Stem Cell Factor (SCF)-induced Interleukin 13 Production by Mast Cells, but Is Dispensable for SCF-dependent Mast Cell Growth.J Biol Chem 2007 Aug 03;282(31):22573-81 View 1856 categorized literature findings and their references in IPA
Molecular Functions
growth factor activity, identical protein binding, protein binding, stem cell factor receptor binding
Protein Domains
growth factor, protein binding, stem cell factor receptor binding, transmembrane domain
Subcellular Locations
cell surface, cellular membrane, cytoplasm, extracellular space, Golgi apparatus, nuclear speckles, nucleus, plasma membrane
