TAF6 - TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Entrez Gene Name: TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Entrez GeneID: Human(6878)
, Mouse(21343), Rat(288533)
, Mouse(21343), Rat(288533) Synonyms: 80kDa, AW549759, DKFZp781E21155, MGC112914, MGC:8964, p80, Taf2-70, TAF2E, TAF6, TAF70, TAFII70, TAFII80, TAFII85, Tata box binding protein-associated factor, tfiid subunit
Gene Summary
- Human (6878): Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
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Biological Process
regulation of transcription factor activity, regulation of transcription, DNA-dependent, RNA elongation from RNA polymerase II promoter, transcription, transcription initiation, transcription initiation from RNA polymerase II promoter
Cellular Components
nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIE complex
Literature References
- 15601843Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R. Core promoter binding by histone-like TAF complexes.Mol Cell Biol 2005 Jan 01;25(1):206-19
- 11583621Bell B, Scheer E, Tora L. Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function.Mol Cell 2001 Sep 1;8(3):591-600
- 7667268Hisatake K, Ohta T, Takada R, Guermah M, Horikoshi M, Nakatani Y, Roeder RG. Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.Proc Natl Acad Sci U S A 1995 Aug 29;92(18):8195-9 View 164 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, general RNA polymerase II transcription factor activity, protein binding, RNA polymerase II transcription factor activity, transcription initiation factor activity
Protein Domains
general RNA polymerase II transcription factor, histone-fold domain, protein binding, transcription regulator
