CHAF1A - chromatin assembly factor 1, subunit A (p150)
Entrez Gene Name: chromatin assembly factor 1, subunit A (p150)
Entrez GeneID: Human(10036)
, Mouse(27221), Rat(363333)
, Mouse(27221), Rat(363333) Synonyms: AL023013, AL024058, Cac1p, CAF-1, CAF-1 P150, CAF1B, CHAF1A, LOC363333, MGC71229, P150
Gene Summary
- Human (10036): Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell cycle, DNA repair, DNA replication, DNA replication-dependent nucleosome assembly, protein complex assembly, regulation of transcription, DNA-dependent, response to DNA damage stimulus, transcription
Literature References
- 15306854Quivy JP, Roche D, Kirschner D, Tagami H, Nakatani Y, Almouzni G. A CAF-1 dependent pool of HP1 during heterochromatin duplication.EMBO J 2004 Sep 01;23(17):3516-26
- 11296234Quivy JP, Grandi P, Almouzni G. Dimerization of the largest subunit of chromatin assembly factor 1: importance in vitro and during Xenopus early development.EMBO J 2001 Apr 17;20(8):2015-27
- 15143166Jiao R, Bachrati CZ, Pedrazzi G, Kuster P, Petkovic M, Li JL, Egli D, Hickson ID, Stagljar I. Physical and Functional Interaction between the Bloom's Syndrome Gene Product and the Largest Subunit of Chromatin Assembly Factor 1.Mol Cell Biol 2004 Jun 01;24(11):4710-9 View 237 categorized literature findings and their references in IPA
Protein Domains
carboxy terminal domain, chromatin binding, dimerization domain, ED domain, KER domain, PCNA binding domain, PEST domain, protein binding
Subcellular Locations
DNA replication foci, nuclear foci, nuclear fraction, nucleus, pericentric heterochromatin
