STXBP1 - syntaxin binding protein 1
Entrez Gene Name: syntaxin binding protein 1
Entrez GeneID: Human(6812)
, Mouse(20910), Rat(25558)
, Mouse(20910), Rat(25558) Synonyms: AI317162, AI326233, ANC18HA, hUNC18, MMS10-G, Ms10g, MUNC-18, MUNC-18A, MUNC18-1, N-SEC1, NSEC1A, Rb-sec1, rbSec1A, rbSec1B, Rsly1, Sec1, STXBP1, Sxtbp1, UNC18, Unc18h
Gene Summary
- Rat (25558): inhibits binding of synaptobrevin and SNAP-25 to syntaxin 1A to modulate SNARE complex formation; acts to regulate neurotransmission [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
axon target recognition, membrane fusion, protein transport, synaptic vesicle maturation, transport, vesicle docking during exocytosis, vesicle-mediated transport
Literature References
- 10657302Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van den Berg TK, Missler M, Geuze HJ, Südhof TC. Synaptic assembly of the brain in the absence of neurotransmitter secretion.Science 2000 Feb 4;287(5454):864-9
- 9115738Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC. DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion.Neuron 1997 Mar 1;18(3):453-61
- 16186111Fukuda M, Imai A, Nashida T, Shimomura H. Slp4-a/Granuphilin-a Interacts with Syntaxin-2/3 in a Munc18-2-dependent Manner.J Biol Chem 2005 Nov 25;280(47):39175-84 View 390 categorized literature findings and their references in IPA
Molecular Functions
protein binding, protein N-terminus binding, syntaxin binding, syntaxin-1 binding
Protein Domains
protein binding, protein N-terminus binding, syntaxin binding, syntaxin-1 binding, transporter
Subcellular Locations
clathrin-coated vesicles, cytoplasm, cytoplasmic particles, cytosol, membrane fraction, membrane processes, myelin enriched fraction, plasma membrane, soluble fraction
