EPHB1 - EPH receptor B1
Entrez Gene Name: EPH receptor B1
Entrez GeneID: Human(2047)
, Mouse(270190), Rat(24338)
, Mouse(270190), Rat(24338) Synonyms: 9330129L11, AW488255, C130099E04Rik, Cek6, Efnb1r, ELK, ELKH, ENSMUSG00000074119, Eph receptor b2, EPHB1, Ephb2, EPHRIN TYPE B RECEPTOR 1, EPHT2, Erk, FLJ37986, Hek6, NET
Gene Summary
- Human (2047): Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq]
- Rat (24338): brain-specific receptor tyrosine kinase with an elk coding sequence [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
axon guidance, camera-type eye morphogenesis, cell-cell signaling, central nervous system projection neuron axonogenesis, cranial nerve development, nervous system development, optic nerve morphogenesis, protein amino acid phosphorylation, retinal ganglion cell axon guidance, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
cytoplasm, integral to membrane, integral to plasma membrane, membrane, membrane raft, plasma membrane
Literature References
- 12971893Williams SE, Mann F, Erskine L, Sakurai T, Wei S, Rossi DJ, Gale NW, Holt CE, Mason CA, Henkemeyer M. Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm.Neuron 2003 Sep 11;39(6):919-35
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 9499402Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.Genes Dev 1998 Mar 1;12(5):667-78 View 427 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, axon guidance receptor activity, ephrin receptor activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, receptor activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity
Protein Domains
axon guidance receptor, cytoplasmic domain, extracellular domain, Fibronectin type III domain, kinase, ligand-binding domain, protein binding, protein-tyrosine kinase, SAM domain, transmembrane-ephrin receptor
Subcellular Locations
cell surface, cellular membrane, dendrites, dendritic spines, nucleus, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic membrane, synapse, synaptic plasma membrane fractions, synaptosomal fractions
