P2RY8 - purinergic receptor P2Y, G-protein coupled, 8
Entrez Gene Name: purinergic receptor P2Y, G-protein coupled, 8
Entrez GeneID: Human(286530)
Synonyms: MGC50878, P2RY8, P2Y8
Gene Summary
- Human (286530): The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Binds:
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Literature References
- 12130504Idzko M, Dichmann S, Ferrari D, Di Virgilio F, la Sala A, Girolomoni G, Panther E, Norgauer J. Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors.Blood 2002 Aug 1;100(3):925-32
- 10727529Boyer JL, Delaney SM, Villanueva D, Harden TK. A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates.Mol Pharmacol 2000 Apr 1;57(4):805-10
- 16714330Jungert K, Buck A, Buchholz M, Wagner M, Adler G, Gress TM, Ellenrieder V. Smad-Sp1 complexes mediate TGFbeta-induced early transcription of oncogenic Smad7 in pancreatic cancer cells.Carcinogenesis 2006 Dec 01;27(12):2392-401 View 39 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, purinergic nucleotide receptor activity, G-protein coupled, receptor activity
