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HTR1E - 5-hydroxytryptamine (serotonin) receptor 1E
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 1E
Entrez GeneID: Human(3354), Mouse(107927)
Synonyms: 5-HT1E, 5-HTR1E, HTR1E, Htr1ea

Gene Summary

No Data Available

Cell Regulation

Regulates:
  • Plc
View all 2 in IPA
Regulated by:
  • clozapine
  • quetiapine
  • methylergonovine
View all 12 in IPA
Binds:
  • ergotamine
  • 5-hydroxytryptamine
  • eletriptan
View all 7 in IPA
Role in cell:
  • aggregation
View all 2 in IPA
Disease:
  • migraines
  • anxiety
  • obesity
View all 5 in IPA

Biological Process

G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, inhibition of adenylate cyclase activity by serotonin receptor signaling pathway, serotonin receptor signaling pathway, signal transduction, synaptic transmission

Cellular Components

integral to plasma membrane, membrane, plasma membrane

Literature References

  • 11114882Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system.Genes Dev 2000 Dec 01;14(23):2919-37
  • 15128784Idzko M, Panther E, Stratz C, Müller T, Bayer H, Zissel G, Dürk T, Sorichter S, Di Virgilio F, Geissler M, Fiebich B, Herouy Y, Elsner P, Norgauer J, Ferrari D. The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release.J Immunol 2004 May 15;172(10):6011-9
  • 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
  • View 53 categorized literature findings and their references in IPA

Molecular Functions

G-protein coupled receptor activity, protein binding, receptor activity, serotonin binding, serotonin receptor activity

Protein Domains

G-protein coupled receptor, protein binding, serotonin receptor

Subcellular Locations

cellular membrane, plasma membrane

IPA Extras

View additional information available in IPA's curated and annotated database: