BLVRA - biliverdin reductase A
Entrez Gene Name: biliverdin reductase A
Entrez GeneID: Human(644)
, Mouse(109778), Rat(116599)
, Mouse(109778), Rat(116599) Synonyms: 0610006A11Rik, 2500001N03Rik, BLVR, BLVRA, BVR, BVRA
Gene Summary
- Human (644): Biliverdin reductases, such as BLVRA (EC 1.3.1.24), catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH (Komuro et al., 1996 [PubMed 8950184]).[supplied by OMIM]
- Rat (116599): catalyzes the conversion of biliverdin to bilirubin in heme degradation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Literature References
- 17639074Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase.FASEB J 2007 Dec 01;21(14):3949-62
- 15741166Miralem T, Hu Z, Torno MD, Lelli KM, Maines MD. Small Interference RNA-mediated Gene Silencing of Human Biliverdin Reductase, but Not That of Heme Oxygenase-1, Attenuates Arsenite-mediated Induction of the Oxygenase and Increases Apoptosis in 293A Kidney Cells.J Biol Chem 2005 Apr 29;280(17):17084-92
- 11773068Ahmad Z, Salim M, Maines MD. Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress.J Biol Chem 2002 Mar 15;277(11):9226-32 View 107 categorized literature findings and their references in IPA
Molecular Functions
biliverdin reductase activity, binding, catalytic activity, metal ion binding, nucleotide binding, oxidoreductase activity, zinc ion binding
