HTR7 - 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
Entrez GeneID: Human(3363)
, Mouse(15566), Rat(65032)
, Mouse(15566), Rat(65032) Synonyms: 5-HT7, HTR7, MGC151363, Serotonin receptor 7
Gene Summary
- Human (3363): The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq]
- Rat (65032): receptor for 5-hydroxytryptamine; involved in modulatory action on cerebellar function [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of adenylate cyclase activity by serotonin receptor signaling pathway, blood circulation, circadian rhythm, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, serotonin receptor signaling pathway, signal transduction, synaptic transmission
Literature References
- 17463246Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Boström K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Råstam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjögren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.Science 2007 06 1;316(5829):1331-6
- 17940054Stull MA, Pai V, Vomachka AJ, Marshall AM, Jacob GA, Horseman ND. Mammary gland homeostasis employs serotonergic regulation of epithelial tight junctions.Proc Natl Acad Sci U S A 2007 Oct 16;104(42):16708-13
- 16120784Kvachnina E, Liu G, Dityatev A, Renner U, Dumuis A, Richter DW, Dityateva G, Schachner M, Voyno-Yasenetskaya TA, Ponimaskin EG. 5-HT7 receptor is coupled to G alpha subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology.J Neurosci 2005 Aug 24;25(34):7821-30 View 138 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, neurotransmitter receptor activity, receptor activity, serotonin receptor activity, signal transducer activity
