HTR5A - 5-hydroxytryptamine (serotonin) receptor 5A
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 5A
Entrez GeneID: Human(3361)
, Mouse(15563), Rat(25689)
, Mouse(15563), Rat(25689) Synonyms: 5-HT5A, Htr5, HTR5A, MGC138226
Gene Summary
- Human (3361): The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq]
- Rat (25689): receptor for serotonin; involved in mediating serotonergic activity in the brain [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
brain development, cAMP-mediated signaling, G-protein coupled receptor protein signaling pathway, signal transduction
Literature References
- 7682702Erlander MG, Lovenberg TW, Baron BM, de Lecea L, Danielson PE, Racke M, Slone AL, Siegel BW, Foye PE, Cannon K, et al.. Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain.Proc Natl Acad Sci U S A 1993 Apr 15;90(8):3452-6
- 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53
- 10197537Grailhe R, Waeber C, Dulawa SC, Hornung JP, Zhuang X, Brunner D, Geyer MA, Hen R. Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor.Neuron 1999 Mar 1;22(3):581-91 View 38 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, G-protein coupled serotonin receptor activity, receptor activity, serotonin receptor activity, signal transducer activity
Protein Domains
G-protein coupled receptor, G-protein coupled serotonin receptor, serotonin receptor, transcription factor
