EDEM3 - ER degradation enhancer, mannosidase alpha-like 3
Entrez Gene Name: ER degradation enhancer, mannosidase alpha-like 3
Entrez GeneID: Human(80267)
, Mouse(66967), Rat(289085)
, Mouse(66967), Rat(289085) Synonyms: 2310050N11RIK, C1ORF22, EDEM3, RGD1561496
Gene Summary
- Human (80267): Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Binds:
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| Disease:
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Biological Process
glycoprotein catabolic process, proteasomal ubiquitin-dependent protein catabolic process, response to unfolded protein
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 16431915Hirao K, Natsuka Y, Tamura T, Wada I, Morito D, Natsuka S, Romero P, Sleno B, Tremblay LO, Herscovics A, Nagata K, Hosokawa N. EDEM3, a Soluble EDEM Homolog, Enhances Glycoprotein Endoplasmic Reticulum-associated Degradation and Mannose Trimming.J Biol Chem 2006 Apr 07;281(14):9650-8
- 14988562Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. Control of pancreas and liver gene expression by HNF transcription factors.Science 2004 02 27;303(5662):1378-81 View 24 categorized literature findings and their references in IPA
Molecular Functions
calcium ion binding, glycoprotein endo-alpha-1,2-mannosidase activity, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
