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EAPP - E2F-associated phosphoprotein
Entrez Gene Name: E2F-associated phosphoprotein
Synonyms: 1810011O16Rik, BM036, C14orf11, EAPP, FLJ20578, MGC189134, MGC4957, RGD1309624

Gene Summary

  • Human (55837): This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. [provided by RefSeq]

Cell Regulation

Regulates:
  • CDKN2A
View all 2 in IPA
Regulated by:
  • No Data Available
Binds:
  • UBQLN4
  • UBE3A
  • E2F3
View all 6 in IPA
Role in cell:
  • quantity
View all 1 in IPA
Disease:
  • No Data Available

Biological Process

No Data Available

Cellular Components

cytoplasm, Golgi apparatus, nucleus

Literature References

  • 15716352Novy M, Pohn R, Andorfer P, Novy-Weiland T, Galos B, Schwarzmayr L, Rotheneder H. EAPP, a Novel E2F Binding Protein That Modulates E2F-dependent Transcription.Mol Biol Cell 2005 May 01;16(5):2181-90
  • 16713569Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.Cell 2006 May 19;125(4):801-14
  • 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 Oct 20;437(7062):1173-8
  • View 50 categorized literature findings and their references in IPA

Molecular Functions

No Data Available

Pathways

No Data Available

Protein Domains

No Data Available

Subcellular Locations

cytoplasm, nucleus

IPA Extras

View additional information available in IPA's curated and annotated database: