EDEM2 - ER degradation enhancer, mannosidase alpha-like 2
Entrez Gene Name: ER degradation enhancer, mannosidase alpha-like 2
Entrez GeneID: Human(55741)
, Mouse(108687), Rat(296304)
, Mouse(108687), Rat(296304) Synonyms: 9530090G24RIK, AI327354, bA4204.1, C20orf31, C20orf49, EDEM2, FLJ10783, MGC93956, RGD1303074, RP23-388H13.1
Gene Summary
- Human (55741): In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulates:
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Literature References
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68 View 11 categorized literature findings and their references in IPA
