SOAT2 - sterol O-acyltransferase 2
Entrez Gene Name: sterol O-acyltransferase 2
Entrez GeneID: Human(8435)
, Mouse(223920), Rat(266770)
, Mouse(223920), Rat(266770) Synonyms: ACACT2, ACAT2, ARGP2, D15Wsu97e, MGC116732, MGC36039, SOAT2, STEROL O-ACYLTRANSFERASE 2
Gene Summary
- Human (8435): Summary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
cholesterol efflux, cholesterol esterification, cholesterol homeostasis, cholesterol metabolic process, foam cell differentiation, intestinal cholesterol absorption, lipid metabolic process, response to nutrient, steroid metabolic process, very-low-density lipoprotein particle assembly
Cellular Components
brush border, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, membrane fraction, microsome
Literature References
- 17431188Bell TA, Kelley K, Wilson MD, Sawyer JK, Rudel LL. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice.Arterioscler Thromb Vasc Biol 2007 Jun 01;27(6):1396-402
- 10846185Chang CC, Sakashita N, Ornvold K, Lee O, Chang ET, Dong R, Lin S, Lee CY, Strom SC, Kashyap R, Fung JJ, Farese RV, Patoiseau JF, Delhon A, Chang TY. Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine.J Biol Chem 2000 Sep 8;275(36):28083-92
- 12518025Chao H, Zhou M, McIntosh A, Schroeder F, Kier AB. ACBP and cholesterol differentially alter fatty acyl CoA utilization by microsomal ACAT.J Lipid Res 2003 Jan;44(1):72-83 View 75 categorized literature findings and their references in IPA
Molecular Functions
acyl-CoA binding, acyltransferase activity, cholesterol binding, cholesterol O-acyltransferase activity, ergosterol O-acyltransferase activity, lanosterol O-acyltransferase activity, sterol O-acyltransferase activity, transferase activity
Subcellular Locations
cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, nuclear envelope
