KATNA1 - katanin p60 (ATPase-containing) subunit A 1
Entrez Gene Name: katanin p60 (ATPase-containing) subunit A 1
Entrez GeneID: Human(11104)
, Mouse(23924), Rat(292464)
, Mouse(23924), Rat(292464) Synonyms: KATNA1, p60 KATANIN
Gene Summary
- Human (11104): Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. [provided by RefSeq]
- Rat (292464): p60 ATPase-containing subunit of katanin, a heterodimeric enzyme (together with p80 subunit Katnb1) responsible for severing microtubules from the centrosome [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cell cycle, cell division, cytoplasmic microtubule organization, interphase of mitotic cell cycle, mitosis, neuron migration, protein localization
Cellular Components
axon, centrosome, cytoplasm, lipid particle, microtubule, nucleus, plasma membrane, spindle, spindle pole
Literature References
- 16203747Toyo-Oka K, Sasaki S, Yano Y, Mori D, Kobayashi T, Toyoshima YY, Tokuoka SM, Ishii S, Shimizu T, Muramatsu M, Hiraiwa N, Yoshiki A, Wynshaw-Boris A, Hirotsune S. Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.Hum Mol Genet 2005 11 1;14(21):3113-28
- 15944385Yu W, Solowska JM, Qiang L, Karabay A, Baird D, Baas PW. Regulation of microtubule severing by katanin subunits during neuronal development.J Neurosci 2005 06 8;25(23):5573-83
- 15215300Karabay A, Yu W, Solowska JM, Baird DH, Baas PW. Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules.J Neurosci 2004 06 23;24(25):5778-88 View 184 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATPase activity, dynein binding, hydrolase activity, microtubule binding, microtubule-severing ATPase activity, nucleoside-triphosphatase activity, nucleotide binding, protein binding, protein heterodimerization activity
Protein Domains
AAA domain, ATP binding, ATPase, dynein binding, enzyme, microtubule binding, Microtubule-severing ATPase, protein binding, protein heterodimerization
Subcellular Locations
axon terminals, axons, cell body, centrosome, cytoplasm, dendrites, growth cone, mitotic spindle, pericentrosomal region, sensory axons, spindle pole
