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GRINA - glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
Entrez Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
Entrez GeneID: Human(2907), Mouse(66168), Rat(266668)
Synonyms: 1110025J15RIK, GRINA, HNRGW, Lag, MGC99687, NMDARA1, TMBIM3

Gene Summary

  • Rat (266668): subunit of the N-methyl-D-aspartate receptor; activation leads to opening of a cation selective channel [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • Ca2+
  • calcium
  • NOS1
View all 46 in IPA
Regulated by:
  • L-glutamic acid
  • SRC
  • pregnenolone sulfate
View all 112 in IPA
Binds:
  • No Data Available
Role in cell:
  • cell death
  • influx in
  • apoptosis
View all 24 in IPA
Disease:
  • Huntington's disease
  • hallucination
View all 4 in IPA

Biological Process

negative regulation of apoptosis

Cellular Components

integral to membrane, membrane

Literature References

  • 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53
  • 17188796Fan MM, Raymond LA. N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease.Prog Neurobiol 2007 Apr 01;81(5-6):272-93
  • 11144360Ehlers MD. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting.Neuron 2000 Nov 1;28(2):511-25
    • View 526 categorized literature findings and their references in IPA

Molecular Functions

cation channel activity

Pathways

Protein Domains

ion channel, N-methyl-D-aspartate selective glutamate receptor

Subcellular Locations

No Data Available

IPA Extras

View additional information available in IPA's curated and annotated database: