HTR3C - 5-hydroxytryptamine (serotonin) receptor 3, family member C
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 3, family member C
Entrez GeneID: Human(170572)
Synonyms: HTR3C
Gene Summary
- Human (170572): The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Literature References
- 15128784Idzko M, Panther E, Stratz C, Müller T, Bayer H, Zissel G, Dürk T, Sorichter S, Di Virgilio F, Geissler M, Fiebich B, Herouy Y, Elsner P, Norgauer J, Ferrari D. The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release.J Immunol 2004 May 15;172(10):6011-9
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 18593952Mastrangelo L, Cassidy A, Mulholland F, Wang W, Bao Y. Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells.Cancer Res 2008 Jul 01;68(13):5487-91 View 47 categorized literature findings and their references in IPA
Molecular Functions
extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity
Protein Domains
extracellular ligand binding domain, ion channel, neurotransmitter-gated ion channel ligand binding domain
