HTR3E - 5-hydroxytryptamine (serotonin) receptor 3, family member E
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 3, family member E
Entrez GeneID: Human(285242)
Synonyms: 5-HT3c1, HTR3E, LOC285241, MGC120035, MGC120036, MGC120037
Gene Summary
- Human (285242): The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes a subunit E of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Literature References
- 15128784Idzko M, Panther E, Stratz C, Müller T, Bayer H, Zissel G, Dürk T, Sorichter S, Di Virgilio F, Geissler M, Fiebich B, Herouy Y, Elsner P, Norgauer J, Ferrari D. The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release.J Immunol 2004 May 15;172(10):6011-9
- 18593952Mastrangelo L, Cassidy A, Mulholland F, Wang W, Bao Y. Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells.Cancer Res 2008 Jul 01;68(13):5487-91
- 12951153Sonda S, Kawahara T, Murozono T, Sato N, Asano K, Haga K. Design and synthesis of orally active benzamide derivatives as potent serotonin 4 receptor agonist.Bioorg Med Chem 2003 09 15;11(19):4225-34 View 46 categorized literature findings and their references in IPA
Molecular Functions
extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity
Protein Domains
extracellular ligand binding domain, neurotransmitter-gated ion channel ligand binding domain
