EDEM1 - ER degradation enhancer, mannosidase alpha-like 1
Entrez Gene Name: ER degradation enhancer, mannosidase alpha-like 1
Entrez GeneID: Human(9695)
, Mouse(192193), Rat(297504)
, Mouse(192193), Rat(297504) Synonyms: A130059K23Rik, EDEM, EDEM1, FLJ51559, FLJ51560, KIAA0212, mKIAA0212, RGD1563633
Gene Summary
No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
| Disease:
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Cellular Components
endoplasmic reticulum, endoplasmic reticulum membrane, integral to endoplasmic reticulum membrane, integral to membrane, membrane
Literature References
- 16431915Hirao K, Natsuka Y, Tamura T, Wada I, Morito D, Natsuka S, Romero P, Sleno B, Tremblay LO, Herscovics A, Nagata K, Hosokawa N. EDEM3, a Soluble EDEM Homolog, Enhances Glycoprotein Endoplasmic Reticulum-associated Degradation and Mannose Trimming.J Biol Chem 2006 Apr 07;281(14):9650-8
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 18502753Hosokawa N, Wada I, Nagasawa K, Moriyama T, Okawa K, Nagata K. Human XTP3-B Forms an Endoplasmic Reticulum Quality Control Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP.J Biol Chem 2008 Jul 25;283(30):20914-24 View 24 categorized literature findings and their references in IPA
Molecular Functions
alpha-mannosidase activity, calcium ion binding, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, protein binding
Subcellular Locations
cellular membrane, cytoplasm, endoplasmic reticulum lumen, endoplasmic reticulum membrane
