ORAI1 - ORAI calcium release-activated calcium modulator 1
Entrez Gene Name: ORAI calcium release-activated calcium modulator 1
Entrez GeneID: Human(84876)
, Mouse(109305), Rat(304496)
, Mouse(109305), Rat(304496) Synonyms: CRAC, CRACM1, D730049H07Rik, FLJ14466, ORAI1, ORAT1, RGD1311873, Soc channel, TMEM142A
Gene Summary
- Human (84876): CRACM1 is a plasma membrane protein essential for store-operated calcium entry (Vig et al., 2006 [PubMed 16645049]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
calcium ion transport, immune response, ion transport, positive regulation of calcium ion transport, transport
Literature References
- 18059270Vig M, Dehaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels.Nat Immunol 2008 Jan 01;9(1):89-96
- 18448669Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE. Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T-Cells: Puncta and Distal Caps.Mol Biol Cell 2008 Jul 01;19(7):2802-17
- 17224452Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill D, Ambudkar IS. Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx: EVIDENCE FOR SIMILARITIES IN STORE-OPERATED AND CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL COMPONENTS.J Biol Chem 2007 Mar 23;282(12):9105-16 View 42 categorized literature findings and their references in IPA
Molecular Functions
calcium channel activity, calcium ion binding, ion channel activity, store-operated calcium channel activity
