SLC6A11 - solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Entrez Gene Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Entrez GeneID: Human(6538)
, Mouse(243616), Rat(79213)
, Mouse(243616), Rat(79213) Synonyms: D930045G19Rik, E130202I16Rik, GABT3, GABT4, GAT-3, GAT4, SLC6A11
Gene Summary
- Human (6538): Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters, such as SLC6A11.[supplied by OMIM]
- Rat (79213): catalyzes sodium and chloride dependent transport of gamma-aminobutyric acid (GABA) to terminate GABA mediated synaptic activity [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Literature References
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 8262042Whyatt DJ, deBoer E, Grosveld F. The two zinc finger-like domains of GATA-1 have different DNA binding specificities.EMBO J 1993 Dec 15;12(13):4993-5005
- 17989291Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M. The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex.J Neurosci 2007 Nov 07;27(45):12255-66 View 22 categorized literature findings and their references in IPA
Molecular Functions
gamma-aminobutyric acid:sodium symporter activity, neurotransmitter binding, neurotransmitter:sodium symporter activity, symporter activity
