L3MBTL - l(3)mbt-like (Drosophila)
Entrez Gene Name: l(3)mbt-like (Drosophila)
Entrez GeneID: Human(26013)
, Mouse(241764), Rat(311613)
, Mouse(241764), Rat(311613) Synonyms: C630004G01, dJ138B7.3, DKFZp586P1522, FLJ41181, H-L(3)MBT, KIAA0681, L(3)MBT, L3MBTL, L3MBTL1, mKIAA0681, RGD1307316
Gene Summary
- Human (26013): This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
|
Literature References
- 12588862Boccuni P, MacGrogan D, Scandura JM, Stephen ND. The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6).J Biol Chem 2003 04 25;278(17):15412-20
- 10445843Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H. A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes.Oncogene 1999 Jul 1;18(26):3799-809
- 17540172Trojer P, Li G, Sims RJ, Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D. L3MBTL1, a histone-methylation-dependent chromatin lock.Cell 2007 06 1;129(5):915-28 View 84 categorized literature findings and their references in IPA
Molecular Functions
metal ion binding, protein binding, transcription factor activity, zinc ion binding
