UGT1A4 - UDP glucuronosyltransferase 1 family, polypeptide A4
Entrez Gene Name: UDP glucuronosyltransferase 1 family, polypeptide A4
Entrez GeneID: Human(54657)
, Mouse(394433), Rat(574523)
, Mouse(394433), Rat(574523) Synonyms: HUG-BR2, UDPGT, Ugt1, UGT1A4, Ugt1a5, Ugt1a6, UGT1D
Gene Summary
- Human (54657): This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Binds:
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Cellular Components
endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, membrane, microsome
Literature References
- 10836148Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease.Annu Rev Pharmacol Toxicol 2000;40:581-616
- 18556656Basu NK, Kole L, Basu M, Chakraborty K, Mitra PS, Owens IS. The Major Chemical-detoxifying System of UDP-glucuronosyltransferases Requires Regulated Phosphorylation Supported by Protein Kinase C.J Biol Chem 2008 Aug 22;283(34):23048-61
- 16155002Chen S, Beaton D, Nguyen N, Senekeo-Effenberger K, Brace-Sinnokrak E, Argikar U, Remmel RP, Trottier J, Barbier O, Ritter JK, Tukey RH. Tissue-specific, Inducible, and Hormonal Control of the Human UDP-Glucuronosyltransferase-1 (UGT1) Locus.J Biol Chem 2005 Nov 11;280(45):37547-57 View 96 categorized literature findings and their references in IPA
Molecular Functions
glucuronosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring hexosyl groups
