HTR2B - 5-hydroxytryptamine (serotonin) receptor 2B
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 2B
Entrez GeneID: Human(3357)
, Mouse(15559), Rat(29581)
, Mouse(15559), Rat(29581) Synonyms: 5-HT 2B RECEPTOR, 5-HT(2B), 5-HT2B, AJ012488, AV377389, HTR2B
Gene Summary
- Human (3357): Multiple receptor subtypes of serotonin neurotransmitters with multiple physiologic functions have been recognized. The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets; central nervous system effects include neuronal sensitization to tactile stimuli and mediation of hallucinogenic effects of phenylisopropylamine hallucinogens.[supplied by OMIM]
- Rat (29581): G-protein coupled receptor for serotonin [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger, activation of phospholipase C activity by serotonin receptor signaling pathway, blood circulation, G-protein coupled receptor protein signaling pathway, heart development, positive regulation of I-kappaB kinase/NF-kappaB cascade, signal transduction
Literature References
- 12743035Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.EMBO J 2003 May 15;22(10):2411-2421
- 17846081Collet C, Schiltz C, Geoffroy V, Maroteaux L, Launay JM, de Vernejoul MC. The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation.FASEB J 2008 Feb 01;22(2):418-27
- 15831837Setola V, Dukat M, Glennon RA, Roth BL. Molecular Determinants for the Interaction of the Valvulopathic Anorexigen Norfenfluramine with the 5-HT2B Receptor.Mol Pharmacol 2005 Jul 01;68(1):20-33 View 485 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, receptor activity, serotonin binding, serotonin receptor activity, signal transducer activity
