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HTR5B - 5-hydroxytryptamine (serotonin) receptor 5B
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 5B
Synonyms: 5-HT5B, GPR134, HTR5B, MGC141198

Gene Summary

  • Rat (79247): G-protein coupled receptor for serotonin [RGD]

Cell Regulation

Regulates:
  • Plc
View all 1 in IPA
Regulated by:
  • clozapine
  • 5-carboxamidotryptamine
  • methiothepin
View all 13 in IPA
Binds:
  • D-lysergic acid diethylamide
View all 1 in IPA
Role in cell:
  • transepithelial electrical resistance
View all 2 in IPA
Disease:
  • anxiety
View all 1 in IPA

Biological Process

G-protein coupled receptor protein signaling pathway, serotonin receptor signaling pathway, signal transduction

Cellular Components

integral to membrane, membrane, plasma membrane

Literature References

  • 7682702Erlander MG, Lovenberg TW, Baron BM, de Lecea L, Danielson PE, Racke M, Slone AL, Siegel BW, Foye PE, Cannon K, et al.. Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain.Proc Natl Acad Sci U S A 1993 Apr 15;90(8):3452-6
  • 11114882Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system.Genes Dev 2000 Dec 01;14(23):2919-37
  • 17122082Papageorgiou A, Denef C. Estradiol Induces Expression of 5-Hydroxytryptamine (5-HT) 4, 5-HT5, and 5-HT6 Receptor Messenger Ribonucleic Acid in Rat Anterior Pituitary Cell Aggregates and Allows Prolactin Release via the 5-HT4 Receptor.Endocrinology 2007 Mar 01;148(3):1384-95
  • View 51 categorized literature findings and their references in IPA

Molecular Functions

drug binding, G-protein coupled receptor activity, receptor activity, serotonin binding, serotonin receptor activity, signal transducer activity

Protein Domains

G-protein coupled receptor, serotonin receptor

Subcellular Locations

cell surface, cellular membrane, plasma membrane

IPA Extras

View additional information available in IPA's curated and annotated database: