E2F7 - E2F transcription factor 7
Entrez Gene Name: E2F transcription factor 7
Entrez GeneID: Human(144455)
, Mouse(52679), Rat(314818)
, Mouse(52679), Rat(314818) Synonyms: A630014C11Rik, D10ERTD739E, E2F7, FLJ12981
Gene Summary
- Human (144455): E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell cycle, negative regulation of cell proliferation, regulation of transcription, regulation of transcription, DNA-dependent, transcription
Literature References
- 12893818de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.J Biol Chem 2003 Oct 24;278(43):42041-9
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 18413728Molenaar JJ, Ebus ME, Koster J, van Sluis P, van Noesel CJ, Versteeg R, Caron HN. Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.Cancer Res 2008 Apr 15;68(8):2599-609 View 46 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, identical protein binding, transcription factor activity, transcription repressor activity
Protein Domains
protein self binding, transcription factor, transcription regulator, transcriptional repressor
