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KANK1 - KN motif and ankyrin repeat domains 1
Entrez Gene Name: KN motif and ankyrin repeat domains 1
Synonyms: A930031B09RIK, ANKRD15, ANKYRIN REPEAT DOMAIN PROTEIN 15, AU015049, AW121052, D330024H06Rik, DKFZp451G231, KANK, KANK1, KIAA0172, MGC125169, MGC43128, MGC90826, mKIAA0172

Gene Summary

  • Human (23189): This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggested role for this protein is in tumorigenesis of renal cell carcinoma. Two alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Cell Regulation

Regulates:
  • No Data Available
Regulated by:
  • ARHGDIG
  • TREM1
View all 4 in IPA
Binds:
  • MIR183 (includes EG:406959)
  • MIR124-2
View all 4 in IPA
Role in cell:
  • No Data Available
Disease:
  • bipolar affective disorder
View all 1 in IPA

Biological Process

negative regulation of actin filament polymerization, negative regulation of cell cycle

Cellular Components

cytoplasm

Literature References

  • 15685193Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs.Nature 2005 02 17;433(7027):769-73
  • 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
  • 18292579Dower K, Ellis DK, Saraf K, Jelinsky SA, Lin LL. Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide.J Immunol 2008 Mar 01;180(5):3520-34
  • View 14 categorized literature findings and their references in IPA

Molecular Functions

No Data Available

Pathways

No Data Available

Protein Domains

ankyrin repeat, DNA binding, transcription factor, transcription regulator

Subcellular Locations

cytoplasm, nucleus

IPA Extras

View additional information available in IPA's curated and annotated database: