KLK10 - kallikrein-related peptidase 10
Entrez Gene Name: kallikrein-related peptidase 10
Entrez GeneID: Human(5655)
, Mouse(69540), Rat(292850)
, Mouse(69540), Rat(292850) Synonyms: 2300002A13Rik, KALLIKREIN 10, KLK10, NES1, PRRSL1, PRSSL1
Gene Summary
- Human (5655): Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
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Literature References
- 11691827Li B, Goyal J, Dhar S, Dimri G, Evron E, Sukumar S, Wazer DE, Band V. CpG methylation as a basis for breast tumor-specific loss of NES1/kallikrein 10 expression.Cancer Res 2001 Nov 1;61(21):8014-21
- 10969073Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA. Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.J Biol Chem 2000 Dec 1;275(48):37397-406
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68 View 66 categorized literature findings and their references in IPA
