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HTR1F - 5-hydroxytryptamine (serotonin) receptor 1F
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 1F
Synonyms: 5-HT1F, 5HT6, Htr1eb, HTR1EL, HTR1F, MR77

Gene Summary

  • Rat (60448): G-protein coupled receptor for serotonin [RGD]

Cell Regulation

Regulates:
  • Plc
  • calcium
View all 3 in IPA
Regulated by:
  • risperidone
  • clozapine
  • tamsulosin
View all 23 in IPA
Binds:
  • sumatriptan
  • 5-hydroxytryptamine
  • ergotamine
View all 8 in IPA
Role in cell:
  • aggregation
View all 2 in IPA
Disease:
  • migraines
  • obesity
View all 4 in IPA

Biological Process

G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, signal transduction, synaptic transmission

Cellular Components

integral to membrane, integral to plasma membrane, membrane, plasma membrane

Literature References

  • 8384716Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2184-8
  • 8380639Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.Proc Natl Acad Sci U S A 1993 Jan 15;90(2):408-12
  • 11114882Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system.Genes Dev 2000 Dec 01;14(23):2919-37
  • View 109 categorized literature findings and their references in IPA

Molecular Functions

G-protein coupled receptor activity, receptor activity, serotonin binding, serotonin receptor activity, signal transducer activity

Protein Domains

adrenoceptor, G-protein coupled receptor, serotonin receptor

Subcellular Locations

cellular membrane, membrane fraction, plasma membrane

IPA Extras

View additional information available in IPA's curated and annotated database: