ADRA2C - adrenergic, alpha-2C-, receptor
Entrez Gene Name: adrenergic, alpha-2C-, receptor
Entrez GeneID: Human(152)
, Mouse(11553), Rat(24175)
, Mouse(11553), Rat(24175) Synonyms: a 2C, ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, Alpha 2c adrenergic receptor, Alpha2-c4, alpha2C, Alpha2c Adrenoceptor, ALPHA2C AR, ALPHA2C-ANRENOCEPTOR
Gene Summary
- Human (152): Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, cell-cell signaling, G-protein coupled receptor protein signaling pathway, signal transduction
Cellular Components
axon, endosome, integral to membrane, integral to plasma membrane, membrane, plasma membrane
Literature References
- 12068299Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L. Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo.Nat Genet 2002 Jul 1;31(3):311-5
- 16757535Prinster SC, Holmqvist TG, Hall RA. {alpha}2C-Adrenergic Receptors Exhibit Enhanced Surface Expression and Signaling upon Association with beta2-Adrenergic Receptors.J Pharmacol Exp Ther 2006 Sep 01;318(3):974-81
- 16033418Bauer A, Zilles K, Matusch A, Holzmann C, Riess O, von Hörsten S. Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation.J Neurochem 2005 Aug 01;94(3):639-50 View 691 categorized literature findings and their references in IPA
Molecular Functions
adrenoceptor activity, alpha2-adrenergic receptor activity, G-protein coupled receptor activity, protein binding, receptor activity, signal transducer activity
Protein Domains
alpha2-adrenergic receptor, G-protein coupled receptor, intracellular loop, protein binding
Subcellular Locations
axons, cellular membrane, intracellular space, perinuclear region, plasma membrane
