PRKCD - protein kinase C, delta
Entrez Gene Name: protein kinase C, delta
Entrez GeneID: Human(5580)
, Mouse(18753), Rat(170538)
, Mouse(18753), Rat(170538) Synonyms: AI385711, Ca+-independent PKC, D14Ertd420e, MAY1, MGC49908, novel Pkc delta, nPKC-delta, PKC DELTA, PKC D , PKCD, PRKCD
Gene Summary
- Human (5580): Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]
- Rat (170538): mediates mitochondrial-dependent apoptosis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
aging, aspartate transport, B cell proliferation, cellular response to glucose starvation, cellular response to insulin stimulus, collagen metabolic process, immunoglobulin mediated immune response, induction of apoptosis, interleukin-10 production, interleukin-12 production, intracellular signaling cascade, negative regulation of insulin receptor signaling pathway, negative regulation of peptidyl-tyrosine phosphorylation, negative regulation of protein binding, positive regulation of apoptosis, positive regulation of glucose import, positive regulation of MAP kinase activity, positive regulation of MAPKKK cascade, protein amino acid autophosphorylation, protein amino acid phosphorylation, protein stabilization, regulation of receptor activity, response to amino acid stimulus, response to drug, response to ethanol, response to glucose stimulus, response to heat, response to hydrogen peroxide, response to hypoxia, response to mechanical stimulus, response to organic cyclic substance, response to organic nitrogen, response to oxidative stress, senescence
Literature References
- 12426377DeVries TA, Neville MC, Reyland ME. Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence.EMBO J 2002 Nov 15;21(22):6050-6060
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89
- 9858769Herdegen T, Leah JD. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.Brain Res Brain Res Rev 1998 Dec;28(3):370-490 View 4742 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, calcium-independent protein kinase C activity, diacylglycerol binding, enzyme activator activity, enzyme binding, insulin receptor substrate binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein C-terminus binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity, transferase activity, zinc ion binding
- RAR Activation
- Mechanisms of Viral Exit from Host Cells
- Natural Killer Cell Signaling
- CCR5 Signaling in Macrophages
- Axonal Guidance Signaling
- ERK/MAPK Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Corticotropin Releasing Hormone Signaling
- Endothelin-1 Signaling
- 14-3-3-mediated Signaling
- Synaptic Long Term Depression
- Prolactin Signaling
- CREB Signaling in Neurons
- Calcium-induced T Lymphocyte Apoptosis
- Aldosterone Signaling in Epithelial Cells
- Huntington's Disease Signaling
- Neuregulin Signaling
- Inositol Phosphate Metabolism
- CXCR4 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- G Beta Gamma Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Synaptic Long Term Potentiation
- Fc Epsilon RI Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
- Glioma Signaling
- IL-12 Signaling and Production in Macrophages
- HGF Signaling
- Renin-Angiotensin Signaling
- GNRH Signaling
- Molecular Mechanisms of Cancer
- Nicotinate and Nicotinamide Metabolism
- Cholecystokinin/Gastrin-mediated Signaling
- Type II Diabetes Mellitus Signaling
- NF-κB Activation by Viruses
- Xenobiotic Metabolism Signaling
- mTOR Signaling
- Melatonin Signaling
- CCR3 Signaling in Eosinophils
- Nitric Oxide Signaling in the Cardiovascular System
- p70S6K Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- NRF2-mediated Oxidative Stress Response
- LPS-stimulated MAPK Signaling
- fMLP Signaling in Neutrophils
- Growth Hormone Signaling
- Leukocyte Extravasation Signaling
- Virus Entry via Endocytic Pathways
- Hepatic Cholestasis
- Thrombopoietin Signaling
- VDR/RXR Activation
- Androgen Signaling
- IL-8 Signaling
- Erythropoietin Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
Protein Domains
Alcohol group acceptor phosphotransferase, C1 domain, C1A domain, C1B domain, calcium independent protein kinase C, catalytic domain, enzyme activator, enzyme binding, hydrophobic domain, kinase, kinase domain, protein binding, protein C-terminus binding, Protein kinase, protein serine/threonine kinase, regulatory domain
Subcellular Locations
cell periphery, cellular membrane, centrosome, cilia, cytoplasm, cytoplasmic fraction, cytoplasmic vesicles, cytoskeletal fraction, cytoskeleton, cytosol, cytosolic fraction, dendrites, dendritic knobs, detergent resistant lipid raft fraction, granules, membrane fraction, microsomal fraction, mitochondria, nucleus, perinuclear region, perinuclear space, plasma membrane, soluble fraction
