KTN1 - kinectin 1 (kinesin receptor)
Entrez Gene Name: kinectin 1 (kinesin receptor)
Entrez GeneID: Human(3895)
, Mouse(16709), Rat(361029)
, Mouse(16709), Rat(361029) Synonyms: CG1, KIAA0004, KINECTIN, KNT, KTN1, MGC133337, MU-RMS-40.19
Gene Summary
- Human (3895): Various cellular organelles and vesicles are transported along the microtubules in the cytoplasm. Likewise, membrane recycling of the endoplasmic reticulum (ER), Golgi assembly at the microtubule organizing center, and alignment of lysosomes along microtubules are all related processes. The transport of organelles requires a special class of microtubule-associated proteins (MAPs). One of these is the molecular motor kinesin (see MIM 148760 and MIM 600025), an ATPase that moves vesicles unidirectionally toward the plus end of the microtubule. Another such MAP is kinectin, a large integral ER membrane protein. Antibodies directed against kinectin have been shown to inhibit its binding to kinesin.[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Cellular Components
endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, integral to plasma membrane, membrane, membrane fraction
Literature References
- 11689693Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P. Kinectin is a key effector of RhoG microtubule-dependent cellular activity.Mol Cell Biol 2001 Dec 1;21(23):8022-34
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363 View 83 categorized literature findings and their references in IPA
Subcellular Locations
cytoplasm, detergent resistant lipid raft fraction, endoplasmic reticulum, membrane vesicles, mitochondrial nucleoids, perinuclear region, pH resistant lipid raft fraction, polyribosome fractions
