ACTR3 - ARP3 actin-related protein 3 homolog (yeast)
Entrez Gene Name: ARP3 actin-related protein 3 homolog (yeast)
Entrez GeneID: Human(10096)
, Mouse(74117), Rat(81732)
, Mouse(74117), Rat(81732) Synonyms: 1200003A09Rik, Actin-like protein 3, ACTR3, ARP3, MGC116163, MGC118188, MGC142370
Gene Summary
- Human (10096): The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. [provided by RefSeq]
- Rat (81732): actin related protein that may participate in the organization of filament/membrane adhesions [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell motion, positive regulation of actin filament polymerization, positive regulation of dendrite morphogenesis, positive regulation of filopodium assembly, positive regulation of lamellipodium assembly, positive regulation of neuron differentiation, regulation of actin filament polymerization, regulation of myosin II filament assembly or disassembly, response to antibiotic, response to carbohydrate stimulus, response to protein stimulus
Cellular Components
actin filament, Arp2/3 protein complex, cell leading edge, cell projection, cytoplasm, cytoskeleton, excitatory synapse, Golgi membrane, hemidesmosome, lamellipodium, podosome
Literature References
- 11395419Higgs HN, Pollard TD. Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.Annu Rev Biochem 2001;70:649-76
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 17220302Yoo Y, Wu X, Guan JL. A Novel Role of the Actin-nucleating Arp2/3 Complex in the Regulation of RNA Polymerase II-dependent Transcription.J Biol Chem 2007 Mar 09;282(10):7616-23 View 443 categorized literature findings and their references in IPA
- fMLP Signaling in Neutrophils
- Actin Cytoskeleton Signaling
- Clathrin-mediated Endocytosis Signaling
- Integrin Signaling
- Regulation of Actin-based Motility by Rho
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Axonal Guidance Signaling
- Ephrin Receptor Signaling
Subcellular Locations
actin tails, cell periphery, cytoplasm, intercellular junctions, lamellipodia, membrane rafts, membrane ruffles, nucleoli, nucleus, perinuclear region, phagosomes, plasma membrane, pseudopodia
