GABRA5 - gamma-aminobutyric acid (GABA) A receptor, alpha 5
Entrez Gene Name: gamma-aminobutyric acid (GABA) A receptor, alpha 5
Entrez GeneID: Human(2558)
, Mouse(110886), Rat(29707)
, Mouse(110886), Rat(29707) Synonyms: A230018I05Rik, Gaba A receptor alpha-5, Gaba A receptor subunit alpha 5, GABAA Alpha 5, GABRA5, LOC727729, MGC138184
Gene Summary
- Human (2558): GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq]
- Rat (29707): subunit of the GABAA receptor; may be part of distinct GABAA receptors within the olfactory bulb [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
associative learning, behavioral fear response, brain development, chloride transport, gamma-aminobutyric acid signaling pathway, ion transport, signal transduction, synaptic transmission, transport
Cellular Components
cell junction, integral to membrane, integral to plasma membrane, membrane, plasma membrane, postsynaptic membrane, synapse
Literature References
- 16230605Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE, Akil H, Watson SJ, Jones EG. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression.Proc Natl Acad Sci U S A 2005 Oct 25;102(43):15653-8
- 12084936Crestani F, Keist R, Fritschy JM, Benke D, Vogt K, Prut L, Blüthmann H, Möhler H, Rudolph U. Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors.Proc Natl Acad Sci U S A 2002 Jun 25;99(13):8980-5
- 10224099Renard S, Olivier A, Granger P, Avenet P, Graham D, Sevrin M, George P, Besnard F. Structural elements of the gamma-aminobutyric acid type A receptor conferring subtype selectivity for benzodiazepine site ligands.J Biol Chem 1999 May 7;274(19):13370-4 View 341 categorized literature findings and their references in IPA
Molecular Functions
chloride channel activity, chloride ion binding, extracellular ligand-gated ion channel activity, GABA-A receptor activity, ion channel activity, neurotransmitter receptor activity, receptor activity, transporter activity
Protein Domains
chloride channel, extracellular ligand binding domain, GABA-A receptor, ion channel, neurotransmitter-gated ion channel ligand binding domain, transporter
