E2F1 - E2F transcription factor 1
Entrez Gene Name: E2F transcription factor 1
Entrez GeneID: Human(1869)
, Mouse(13555), Rat(399489)
, Mouse(13555), Rat(399489) Synonyms: E2f, E2F1, E2f1 predicted, KIAA4009, mKIAA4009, RBAP1, RBBP3, RBP3
Gene Summary
- Human (1869): The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq]
- Rat (399489): transcription factor; involved in controling the G1/S transition of eukaryotic cells [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, cell cycle, cell proliferation, forebrain development, G1 phase of mitotic cell cycle, G1/S transition of mitotic cell cycle, negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription, DNA-dependent, regulation of cell cycle, regulation of transcription, regulation of transcription, DNA-dependent, transcription
Literature References
- 16481464Hallstrom TC, Nevins JR. Jab1 is a specificity factor for E2F1-induced apoptosis.Genes Dev 2006 Mar 01;20(5):613-23
- 12757710Iakova P, Awad SS, Timchenko NA. Aging Reduces Proliferative Capacities of Liver by Switching Pathways of C/EBPalpha Growth Arrest.Cell 2003 May 16;113(4):495-506
- 12065415Wang S, Zhang B, Faller DV. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth.EMBO J 2002 Jun 17;21(12):3019-28 View 4268 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, protein binding, transcription activator activity, transcription corepressor activity, transcription factor activity, transcription factor binding
- Molecular Mechanisms of Cancer
- p53 Signaling
- Prostate Cancer Signaling
- Melanoma Signaling
- Aryl Hydrocarbon Receptor Signaling
- Small Cell Lung Cancer Signaling
- Role of BRCA1 in DNA Damage Response
- Glioma Signaling
- Bladder Cancer Signaling
- Non-Small Cell Lung Cancer Signaling
- Cell Cycle: G1/S Checkpoint Regulation
- Cell Cycle Regulation by BTG Family Proteins
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Pancreatic Adenocarcinoma Signaling
- Chronic Myeloid Leukemia Signaling
Protein Domains
dimerization domain, DNA binding domain, marked box, protein binding, transcription activation domain, transcription co-repressor, transcription factor, transcription factor binding, transcription regulator, transcriptional activator
Subcellular Locations
chromatin, cytoplasm, intranuclear region, nuclear fraction, nucleoplasm, nucleus
